1. 美国专利局，前体阿基瑞林全球专利申请(2013) 2. 西班牙Lipotec 实验室阿基瑞林技术论文 3. 西交大二院，阿基瑞林对中国受试者的抗皱效用 (2012) 4. 抗衰老生物活性物 Argireline 5. 西班牙Granada 大学对阿基瑞林化妆品效用的评估 (2010) 6. 西班牙Valencia 大学对阿基瑞林抗皱效用的评估 (2002) 7. 暨南大学，生物活性多肽护肤品的基础及应用(2002) 8. 国际药妆品牌推介 (2013) 9. 六胜肽Argireline 国际药妆品牌介绍 (2013) 10. 关于阿基瑞林发明实验室 Lipotec 公司 11. 肉毒杆菌机理解释 格瑞复斯科学家科研论著在国际期刊上的部分论文： 1. The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects. Wang Y, Wang M, Xiao XS, Pan P, Li P, Huo J. J Cosmet Laser Ther. 2013 Apr 22. 2. The anti-wrinkle efficacy of Argireline. Wang Y, Wang M, Xiao XS, Huo J, Zhang WD. J Cosmet Laser Ther. 2013 Aug;15(4):237-41. doi: 10.3109/14764172.2013.769273. 3. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. Am J Clin Dermatol. 2013 Apr;14(2):147-53. doi: 10.1007/s40257-013-0009-9. 4. A synthetic hexapeptide (Argireline) with antiwrinkle activity. 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Hayashi Y, Katada J, Harada T, Tachiki A, Iijima K, Takiguchi Y, Muramatsu M, Miyazaki H, Asari T, Okazaki T, Sato Y, Yasuda E, Yano M, Uno I, Ojima I. J Med Chem. 1998 Jun 18;41(13):2345-60. 16. In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and itscarboxyl ester prodrug L-775,318. Roles of efflux and metabolism. Prueksaritanont T, DeLuna P, Gorham LM, Ma B, Cohn D, Pang J, Xu X, Leung K, Lin JH. Drug Metab Dispos. 1998 Jun;26(6):520-7. 17. Adenosine receptor prodrugs: towards kidney-selective dialkylxanthines. Barone S, Churchill PC, Jacobson KA. J Pharmacol Exp Ther. 1989 Jul;250(1):79-85. 18. Zhang Yanmei*；Dan Wei-Xing; Liu Jianqi; Tortorella D. Micky; Tu Zhengchao; Talley J. John*; Palladium-Catalyzed Synthesis of Trimethylsilyl Substituted Benzopyran Derivatives, The Open Organic Chemistry Journal, 2013, 7, 15-20 19. Chan Michael; Hayashi Tomoko; Mathewson Richard D.; Yao Shiyin; Gray Christine; Tawatao Romel I.; Kalenian Kevin; Zhang Yanmei; Hayashi Yuki; Lao Fitzgerald S.; Cottam Howard and Carson Dennis. Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands, Bioconjugate Chemistry, 2011, 22, 445-454. 20. Zhang Yanmei; Saldanha Adrian; Elliott Greg; Tsygelny Igor; Carson Dennis and Wrasidlo Wolf. Synthesis of 5-(6-hydroxy- 7H-purine -8-ylthio)-2- (N-hydroxyformamido) pentanoic acid, Beilstein J. Org. Chem. 2010, 6, 742-747. 21. Hijazi Ahmed; Yeong Hui Yee; Zhang Yanmei; Herdtweck Eberhardt; Nuyken Oskar; Kühn Fritz E. Isobutene Polymerization Using [CuII(NCME)6]2+with Non Coordinating Anions as Catylysts, Macromol. Rapid Com. 2007, 28, 670-675. 22. Nuyken Oskar; Vierle Mario; Kühn Fritz E.; Zhang Yanmei. Solvent-Ligated Transition Metal Complexes as Initiators for the Polymerization of Isobutene, Macromolecular Symposia 2006, 236, 69-77. 23. Zhang Yanmei; Sun Wei; Freund C.; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Cationic copper(I) and silver(I) nitrile complexes with fluorinated weakly coordinating anions: metal-nitrile bond strength and its influence on the catalytic performance, Inorg. Chim. Acta. 2006, 359, 4723-4729. 24. Zhang Yanmei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Organonitrile Ligated Silver Complexes with Perfluorinated Weakly Coordinating Anions as Active Catalysts for Coupling Reactions, New. J. Chem. 2005, 29, 366-370. 25. Zhang Yanmei; Sun Wei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Synthesis, characterization, and catalytic application of Copper(I) nitrile cations with perflurinated weakly coordinating anions, Catalysis Letters 2005, 101, 35-41. 26. Vierle Mario; Zhang Yanmei; Köhler Klaus; Haessner Carmen; Santos Ana M.; Herdtweck Eberhardt; Nuyken Oskar and Kühn Fritz E. Solvent Ligated Manganese (II) Complexes for the Homopolymerization of Isobutene and the Copolymerization of Isobutene and Isoprene, Chem. Eur. J. 2004, 10, 6323-6332. 27. Gago Sandra; Zhang Yanmei; Santos Ana M.; Köhler Klaus; Kühn Fritz E.; Fernandes Jose A.; Pillinger Martyn; Valente Anabela A.; Santos Teresa M.; Ribeiro-Claro Paulo; Goncalves Isabel S. Synthesis and characterization of a Manganese(II) acetonitrile complex supported on functionalized MCM-41, Microporous and Mesoporous Materials, 2004, 76, 131-136. 28. Kühn Fritz E.; Zuo Jing-Lin; Fabrizi de Biani Fabrizia; Santos Ana M.; Zhang Yanmei; Zhao Jin; Sandulache Angela and Herdtweck Eberhardt. 4-Ethynylpyridine as bridging moiety in mixed Ru/Re complexes, New J. Chem. 2004, 28, 43-51. 29. Vierle Mario; Zhang Yanmei; Herdtweck Eberhardt; Bohnenpoll Martin; Nuyken Oskar; Kuhn Fritz E. Highly reactive polyisobutene prepared with manganese(II) complexes as initiators, Angewandte Chemie, International Edition 2003, 42, 1307-1310. 30. Qing Feng-Ling; Ying Jiewen; Zhang Yanmei. A stereoselective synthesis of ethyl 9-cis-7,8-didehydro-19-trifluoromethylretinoate, Journal of Fluorine Chemistry 2000, 101, 31-33. 31. Qing Feng-Ling; Zhang Yanmei. Ethyl 3-Iodo-4,4,4-trifluoro-2(Z) -butenoate: regio- and stereospecific preparation and palladium-catalyzed reaction with terminal alkynes, Tetrahedron Letters 1997, 38, 6729-6732.32.Kochhar JS, Anbalagan P, Shelar SB, Neo JK, Iliescu C, 201433.Majd S, Kang L. Application of Hydrogels in Drug Delivery and Biosensors. Edited book (vol. 3), World Scientific Publishing Co. (Book, in press)34.Nguyen DV, Li F, Li H, Wong BS, Low CY, Liu XY, Kang L. 2014. Drug permeation through skin is inversely correlated with carrier gel rigidity. Molecular Pharmaceutics (minor revision). Impact factor =4.78735.Kwan YH, Tung YK, Kochhar JS, Poh AL, Kang L. Sep 2014. Handbook of cosmeceutical excipients and their safeties. Woodhead Publishing Ltd, Elsevier. (Book Kang L. Jul 2014. Direct microneedle array fabrication off a photomask to deliver collagen through skin. Pharmaceutical Research. 31(7):1724-1734. (Featured by Reuters, http://uk.reuters.com/video/2014/10/18/microneedle-patch-promises-painless-pric?videoId=346623719&videoChannel=4000) Impact factor =3.95236.Kochhar JS, Lim WX S, Zou S, Foo WY, Pan J, Kang L. Nov 2013. Microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine. (Featured by NUS Research Highlights, http://www.science.nus.edu.sg/research-highlights/979-microneedles-for-fast-onset-and-sustained-delivery-of-a-pain-killer) Molecular Pharmaceutics. 10 (11): 4272–4280. Impact factor =4.787, cited by 337.Kochhar JS, Quek TC, Soon WJ, Choi J, Zou S, Kang L. Nov 2013. Effect of microneedle geometry and supporting substrate on microneedle array penetration into skin. Journal of Pharmaceutical Science. 102(11):4100-4108. Impact factor =3.007, cited by 338.Pan J, Chan SY, Common JEA, Amini S, Miserez A, Lane EB, Kang L. Nov 2013. Fabrication of a 3D hair follicle-like hydrogel mould by soft lithography. Journal of Biomedical Materials Research Part A. 101(11):3159-69. (Featured on AAPS blog, http://aapsblog.aaps.org/2013/11/12/grow-human-hair-follicles-in-a-microwell/) Impact factor =2.841, cited by 139.Kochhar JS, Chan SY, Ong PS, Lee WG, Kang L. Oct 2013. Microfluidics for drug discovery and analysis. Microfluidic Devices for Biomedical Applications. Woodhead Publishing. 231-280. (Book chapter) 40.Kang L, Cheong HH, Chan SY, Lim FCP. Applications of small-molecule gels-drug delivery. Sep 2013. Soft Fibrillar Materials. Wiley. 115-128. (Book chapter) 41.Yan J, Wong BS, Kang L. Molecular gel for tissue engineering. Sep 2013. Soft Fibrillar Materials. Wiley. 129-162. (Book chapter) 42.Li H, Yu Y, Dana SF, Li B, Li CY, Kang L. Aug 2013. Novel engineered systems for oral, mucosal and transdermal drug delivery. Journal of Drug Targeting. 21(7): 611–629. (invited review) Impact factor =2.723, cited by 5 43.Kang L, Vaddi H K, Lim PFC, Cheong HH, Chan SY. Jul 2013. Terpenes and Improvement of Transdermal Drug Delivery. Handbook of Natural Products. Springer. 3757-3774. (Book chapter) 44.Faraji-Dana S, Nguyen DV, Kochhar JS, Liu XY, Kang L. Jun 2013. UV-curable pressure sensitive adhesive films: effects of biocompatible plasticizers on mechanical and adhesion properties. (Featured by LabScholars. http://labscholars.com/item/69967) Soft Matter. 9, 6270–6281. Impact factor =4.151, cited by 2 45.Kochhar JS, Goh WJ, Chan SY, Kang L. Feb. 2013. A simple method of microneedle array fabrication for transdermal drug delivery. Drug Development and Industrial Pharmacy. 39:299-309. (Featured on www.MDLinx.com, as an article that matters to physicians and healthcare professionals, http://www.mdlinx.com/pharmacy/news-article.cfm/4408365) Impact factor = 2.006, cited by 9 46.Mah CS, Kochhar JS, Ong PS, Kang L. Jan 2013. A miniaturized flow-through cell to evaluate skin permeation of endoxifen. International Journal of Pharmaceutics. 441:433-440. Impact factor =3.785, cited by 2 2012 47.Goh WJ, Makam VS, Hu J, Kang L, Zheng M, Yoong SL, Udalagama CNB, Pastorin G. Dec. 2012. Iron oxide filled magnetic carbon nanotube-enzyme conjugates for recycling of Amyloglucosidase. Langmuir. 28(49):16864-73. Impact factor = 4.384, cited by 8 48.Wong BS and Kang L. Nov. 2012. Mastery learning in the context of university education. Journal of the NUS Teaching Academy. 2(4), 206-222. New Journal, no impact factor 49.Bauer M, Kang L (co-first author), Qiu Y, Wu J, Peng M, Chen HH, Camci-Unal G, Bayomy AF, Sosnovik DE, Khademhosseini A, Liao R. Nov. 2012. Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLOS One. 7(11):50491e. Impact factor = 3.534, cited by 7 50.Wong BS, Teoh SH, Kang L. Aug. 2012. Polycaprolactone scaffold as targeted drug delivery system and cell attachment scaffold for post-surgical care of limb salvage. Drug Delivery and Translational Research. 2:(4) 272-283. New Journal, no impact factor, cited by 1 51.Kochhar JS, Chan SY, Ong PS and Kang L. Aug. 2012. Clinical therapeutics for phenylketonuria. Drug Delivery and Translational Research. 2:(4) 223-237.(review) New Journal, no impact factor, cited by 1 52.Kochhar JS, Zou S, Chan SY, and Kang L. Jun. 2012. Protein encapsulation in polymeric microneedles by photolithography. International Journal of Nanomedicine. 7:3143-54. Impact factor=4.195,cited by 8 2011 53.Li H, Jiang B, Yan J, Yang Z, Chen Y, Zhang W, Choy AC, Lee M C-Y and Kang L. Dec. 2011. A drug-laden elastomer for surgical treatment of anal fistula. Drug Delivery and Translational Research. 1:439-447. (Featured on front cover) New Journal, no impact factor, cited by 1 54.Pan J, Chan SY, Lee WG, Kang L. Dec. 2011. Microfabricated particulate drug delivery systems. Biotechnology Journal. 11:337-367. (Invited review) Impact factor =3.708, cited by 14 55.Li H, Kochhar JS, Pan J, Chan SY, Kang L. Jun. 2011. Nano/micro-scale technologies for drug delivery. Journal of Mechanics in Medicine and Biology. 11: 337-367. (Invited review) Impact factor = 0.803, cited by 4 56.Chourasia MK, Kang L, Chan SY. May 2011. Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results in Pharma Sciences. 1:60-67. New Journal, no impact factor, cited by 18 2010 57.Kang L, Hancock M, Brigham M, Khademhosseini A. May 2010. Cell confinement within patterned nanoliter droplets in a microwell array. Journal of Biomedical Materials Research Part A. 93:547-557. Impact factor =2.841, cited by 20 2009 58.Kachouie N, Kang L, Khademhosseini A. Sep. 2009. Arraycount, an algorithm for automatic cell counting in microwell arrays. Biotechniques 47(3):x-xvi . Impact factor =2.754, cited by 12 2008 59.Kang L, Chung B, Langer R, Khademhosseini A. Jan. 2008. Microfluidics for drug discovery and development: From target selection to product lifecycle management. Drug Discovery Today. 13:1-13. (Invited Review) Impact factor =5.964, cited by 178 60.Lim PF, Liu XY, Kang L, Ho PC, Chan SY. Jun. 2008. Physicochemical effects of terpenes on organogel for transdermal drug delivery. International Journal of Pharmaceutics. 358:102-7. Impact factor =3.785, cited by 21 2007 61.Chung B, Kang L (co-first author), Khademhosseini A. Dec. 2007. Micro- and nanoscale technologies for tissue engineering and drug discovery applications. Expert Opinion on Drug Discovery. 2(12):1653-1668. (Invited Review) Impact factor = 3.467, cited by 43 62.Kang L, Poh AL, Fan SK, Ho PC, Chan YW, Chan SY. Aug. 2007. Reversible effects of permeation enhancers on human skin. European Journal of Pharmaceutics & Biopharmaceutics. 67(1):149-55. Impact factor = 4.245, cited by 18 63.Kang L, Yap CW, Lim PF, Chen YZ, Ho PC, Chan YW, Wong GP, Chan SY. Jul. 2007. Formulation development of transdermal dosage forms: Quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin. Journal of Controlled Release. 31(3):211-219. Impact factor = 7.261, cited by 35 2006 64.Lim FC P, Liu XY, Kang L, Ho PC, Chan YW, Chan SY. Mar. 2006. Limonene GP1/PG organogel as a vehicle in transdermal delivery of haloperidol. International Journal of Pharmaceutics 311:157-164. Impact factor =3.785, cited by 65 65.Kang L, Ho PC, Chan SY. Jan. 2006. Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids isothermal titration calorimetry study. Journal of Thermal Analysis and Calorimetry 83: 27-30. Impact factor = 2.206, cited by 8 2005 66.Kang L, Liu XY, Sawant PD, Ho PC, Chan YW, Chan SY. Aug. 2005. SMGA gels for the skin permeation of haloperidol. Journal of Controlled Release 106:89-98. Impact factor = 7.261, cited by 54
